Feline – Male Domestic Shorthair

Species: Feline

Breed: Domestic Shorthair

Age: 9-year-old

Gender: Male-Neutered


Patient was diagnosed as pancreatitis and hepatic lipidosis. On ultrasonography, small intestinal obstruction was found, surgical removal was performed.

Low magnification view of the lesion (1X)



Higher magnification view of the lesion (40X)
Click here for the IDEXX Pathology Report on this case.


Multiple sections of intestine are examined. Transmurally infiltrating the intestinal wall and extending into the adjacent omentum is a poorly differentiated round cell neoplasm. Neoplastic round cells contain scant cytoplasm and irregular oval to indented nuclei. Neoplastic round cells frequently contain eosinophilic granules. There are numerous eosinophils and multiple areas of necrosis along with frequent individual cell necrosis. Neoplastic cells extend to the serosal surface.


Intestine: Large granular lymphocyte (LGL) lymphoma

Mitotic count: 21

Margins: Oral and aboral margins are approximately 4.8 and 13 mm.

Vascular invasion: Not noted in the examined sections


Large granular lymphocyte (LGL) lymphoma is typically associated with a poor prognosis and patients respond poorly to therapy. In cats, LGL lymphomas are often primary in the gastrointestinal tract with rapid progression to regional lymph nodes, liver, spleen, and kidneys. Affected patients are often leukemic. A CBC evaluation and additional clinical staging are recommended.

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