Breed: Ibizan Hound
Ophthalmologist diagnosed cancer in globe of left eye.
Interpretation: Left globe: iridocillary adenoma, uveo-invasive type, well differentiated with secondary glaucoma and retinal detachment
Mitotic count: <1
Excision: Completely removed, limited to the interior globe
Vascular Invasion: Not observed.
Iridociliary epithelial tumors are the second most common intraocular neoplasm in dogs, and the fourth most common intraocular neoplasm in cats. It originates from the mature neuroectodermal cells of the pigmented and nonpigmented epithelial cells of the iris and ciliary body. Golden Retrievers and Labrador Retrievers account for 39% of the canine cases.
Adenomas can be non-invasive (limited to the anterior and posterior chambers) or uveo-invasive (invade the uveal stroma). Key differentiating feature of an iridociliary adenocarcinomas from an adenoma are the presence of pleomorphism, high mitotic index and invasion of the choroid and sclera. Malignant iridociliary epithelial neoplasm can be designated either as iridociliary adenocarcinoma or pleomorphic adenocarcinoma. Pleomorphic adenocarcinomas are long standing lesions that invade the whole globe. Whereas iridociliary adenocarcinomas are unlikely to metastasize, pleomorphic adenocarcinomas are likely to metastasize. In contrast to canine cases, approximately 30% of feline cases have osseous metaplasia. This neoplasm has a strong propensity to induce pre-iridal fibrovascular membrane.
Maxie. (ed). 2007. Pathology of Domestic Animals. 5th edition. Vol 1. pp. 542.
- Low magnification view of the lesion, demonstrating a well demarcated, non encapsulated, multilobulated, mass expanding the iris.
- Higher magnification view of the lesion, demonstrating tubules with vague papillary projections, cords and islands of low cuboidal to polygonal cells, supported by a fine, fibrovascular stroma.
Higher magnification view of the lesion, demonstrating tubules lined by well differentiated low cuboidal to polygonal cells.