Breed: German Shepherd
Gender: Female Spayed
Overall the dog has been normal except for leaking some urine with blood the past 2 months. Cystocentesis: urine sample was normal. Discovered this growth while performing digital exam of the vulva / vagina. There was mild to moderate pain, surgically removed. Visually couldn’t determine if good margins obtained as it was a blended with normal tissue. 1 cm firm, red, ulcerated, oval growth located on the floor of the vagina in between the urethral papilla and vulvar opening.
Interpretation: Vagina: Urothelial (transitional cell) carcinoma
Mitotic Count: 2
Excision: Extends to surgical margins
Vascular Invasion: Observed Frequently
Transitional cell carcinomas of the urinary bladder have a variable prognosis depending on the extent of mural invasion, degree of tumor differentiation, degree of associated desmoplastic response, and the length of time the tumor has been present. In general, tumors that are limited to the mucosa (papillary or in situ growth pattern) have a better prognosis than those that invade deeper portions of the bladder wall. All transitional cell carcinomas have at least moderate potential for metastasis to regional lymph nodes and distant sites including the lungs. Highly invasive tumors can extend through the wall and directly into the adjacent peritoneal cavity. Approximately 50% of these tumors eventually metastasize. Distant metastasis occurs more frequently with increasing duration of the tumor.
Fouad Aoun, Hampig Raphael Kourie, Elie El Rassy, and Roland van Velthoven.Bladder and vaginal transitional cell carcinoma: A case report. Oncol Lett. 2016 Sep; 12(3): 2181–2183.