Saint Bernard Case

Species:       CANINE

Breed:          SAINT BERNARD

Age:              6.5 Y

Gender:         FEMALE, SPAYED

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STANDARD BIOPSY W/ DESC (1 SITE)

Test

SOURCE/HISTORY

Mass, left rear paw.

Click here for the IDEXX Pathology Report on this case.

MICROSCOPIC DESCRIPTION

The epidermis is slightly thickened (acanthosis) with moderate orthokeratotic hyperkeratosis. Expanding the dermis are multiple, variably sized, irregularly shaped, accumulations of basophilic granular material which is surrounded by dense fibrovascular connective tissue and moderate numbers of inflammatory cells, mainly macrophages and giant cells. Similar, smaller mineral deposits are randomly scattered outside of the larger foci. The mineral varies from lightly basophilic and slightly granular to deeply basophilic and dense. There are also multiple dilated hair follicles that contain a moderate amount of keratin. Excision is complete.

MICROSCOPIC INTERPRETATION

Haired skin: Dermal mineralization, locally extensive, chronic with acanthosis, histiocytic inflammation and fibrosis, completely removed (compatible with calcinosis circumscripta)

COMMENTS

Calcinosis circumscripta is a nonneoplastic degenerative lesion consisting of tumor-like nodules of mineralized foci surrounded by fibrosis and granulomatous inflammation. It usually is seen as an idiopathic lesion occurring on the distal extremities, over the spine, and in the tongue of young large breed dogs. The cause is not determined; as lesions occur at sites of potential injury, such as pressure points or ear crop margins, mineralization may be dystrophic. Symmetrical lesions have been associated with hypertrophic osteodystrophy and idiopathic arthritis (spontaneous remission of calcinosis circumscripta lesions may occur as the disease becomes inactive). Complete excision of individual lesions is curative.

 

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