PRIORITY BIOPSY W/DESC (1 SITE)
Scaly, 2-3 month duration. Was evidence of skin infection but cytology and fungal culture were negative. Has been unresponsive to Apoquel, Simplicef, and Mal-a-ket wipes.Click here for the IDEXX Pathology Report on this case.
Haired skin: There is extensive, multifocal mineralization of dermal collagen. There are variable associated accumulations of macrophages, lymphocytes and plasma cells. The epidermis is multifocally hyperplastic and there is orthokeratotic hyperkeratosis.
The microscopic lesions are typical of calcinosis cutis. These lesions are due to degeneration of dermal collagen with subsequent dystrophic mineralization and are almost always associated with hyperglucocorticoidism of either endogenous or exogenous cause. Ruling out Cushing’s disease may be indicated. Late stage lesions may progress to osseous metaplasia of the dermis resulting in cutaneous plaque formation (Frazier KS, et. al. “Multiple Cutaneous Metaplastic Ossification Associated with Iatrogenic Hyperglucocorticoidism”. J Vet Diagn Invest 1998; 10:303-307).